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StatisticalMonitoringofClinicalTrials(LemuelA.Moyé,2005)

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StatisticalMonitoringofClinicalTrials(LemuelA.Moyé,2005)
ProductDetailsPaperback:254pagesPublisher:Springer;1edition(Nov162005)Language:EnglishISBN-10:0387277811ISBN-13:978-0387277813ProductDescription:StatisticalMonitoringofClinicalTrials:FundamentalsforInvestigatorsintroducestheinvestigatorandstatisticiantomonitoringproceduresinclinicalresearch.Clearlypresentingthenecessarybackgroundwithlimiteduseofmathematics,thisbookincreasestheknowledge,experience,andintuitionofinvestigationsintheuseoftheseimportantproceduresnowrequiredbythemanyclinicalresearchefforts.Theauthorprovidesmotivatedclinicalinvestigatorsthebackground,correctuse,andinterpretationofthesemonitoringproceduresatanelementarystatisticallevel.Hedefinestermscommonlyusedsuchasgroupsequentialproceduresandstochasticcurtailmentinnon-mathematicallanguageanddiscussesthecommonlyusedproceduresofPocock,O’Brien–Fleming,andLan–DeMets.Hediscussesthenotionsofconditionalpower,monitoringforsafetyandfutility,andmonitoringmultipleendpointsinthestudy.TheuseofmonitoringclinicaltrialsisintroducedinthecontextoftheevolutionofclinicalresearchandonechapterisdevotedtothemorerecentBayesianprocedures. 本软件ID:2323787

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